The Scientific Council ensures that research and development form an integral part of the workload of the primary standardisation centres and that their work is in line with the needs of metrology in the Czech Republic and the state of scientific and technical development in the world.
The Scientific Council has at least 9 members from among external experts and scientific staff of the Institute, appointed by the Director General of the Institute on the basis of their prior approval. The aforementioned external experts are persons who can contribute to the development of the Institute's scientific activities through their scientific work or practical experience. The Director-General of the Institute and his Director of FM are also members of the Scientific Council.
The following members of the Scientific Council were appointed for the term of office from 1 January 2019 to 31 December 2022:
| Prof., Ing.Tomáš Čechák, CSc. | ČVUT |
| Doc., Ing.Stanislav Ďuriš, CSc. | STU Bratislava |
| Ing. Radek Sedláček, Ph.D. | ČVUT |
| RNDr.Tomáš Gronych, CSc. | MFF UK |
| Doc., RNDr.Pavel Janderka, CSc. | Pragolab |
| RNDr. Pavel Klenovský | ČMI |
| Ing. František Mohelský, Ph.D. | Škoda Auto a.s. |
| Prof. RNDr. Miloslav Ohlídal, CSc. | VUT v Brně |
| Mgr. Viktor Pokorný | ÚNMZ |
| Ing.Ondřej Prokeš , Ph.D., MBA | NET4GAS |
| Prof. Ing. Miloslav Suchánek, CSc. | VŠCHT |
| RNDr. Jiří Tesař, PhD. | ČMI |
| Ing. Zbyněk Veselák | ÚNMZ |